The museum consists of the following sections:
- Collectibles section, which includes a prehistoric collection, a collection of Greek vases, Egyptian one, the halls of bronzes, gems and coins.
- Section Prehistoric and Protohistoric: illustrates the evolutionary process that led to the appearance of the human race, presenting the archaeological materials discovered in the Como area.
- The Roman Section, where they are placed the remains of the Roman Como area.
On the ground floor of the museum can be found the Roman Lapidary and a room dedicated to the great mosaic floor from the Roman era discovered in Perti Street, Como.